Sugar acids and derivatives
Medchemexpress LLC BET-IN-14 | 2243669-93-2 | C30H37N7O2 | 5 MG
BET-IN-14 is an orally active pan BET inhibitor with an IC50 of 5.35 nM, demonstrating anti-cancer activity. It is intended for research use only.
- Orally active pan BET inhibitor
- Exhibits anti-cancer activity
- High purity (99.07%)
- Solid, light yellow to yellow appearance
- Soluble in DMSO (100 mg/mL)
- Effective against various cancer cell lines (average IC50: 174.7 nM)
- Inhibits tumor growth in MV-4-11 xenograft models
Medchemexpress LLC 2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide | 1258292-64-6 | 99.8% | 1 ML
GDC-046 (2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide) is a potent, selective, orally bioavailable TYK2 inhibitor with reported Ki values of 4.8 nM (TYK2), 0.7 nM (JAK1), 0.7 nM (JAK2), and 0.4 nM (JAK3). Supplied for research use, available as a 10 mM solution in DMSO (1 mL) or as solid material.
- Potent, selective TYK2 inhibitor with low-nanomolar activity against JAK family kinases.
- Molecular weight 350.2 g/mol; formula C16H13Cl2N3O2.
- CAS 1258292-64-6; purity 99.8%.
- Physical form solid, off-white to yellow; also supplied as 10 mM solution in DMSO (1 mL).
- Solubility in DMSO 62.5 mg/mL (178.47 mM); ultrasonic assistance recommended.
- Storage: solid at 4 °C; in solvent store at -80 °C (up to 6 months) or -20 °C (up to 1 month); protect from light.
Apexbio Technology LLC Beta-Amyloid (1-11) 190436-05-6 25mg
Beta-Amyloid (1-11) (CAS 190436-05-6) is a synthetic peptide fragment derived from the N-terminus of the amyloid precursor protein comprising the amino acid sequence H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-OH This peptide represents a portion of the beta-amyloid (A ) sequence implicated in amyloidogenic pathways associated with neurodegenerative processes particularly Alzheimer s disease Beta-Amyloid (1-11) is utilized in research to investigate amyloid aggregation dynamics immunogenic epitope mapping within the A region and the biochemical properties of amyloidogenic peptides It serves as a molecular tool in studies examining the early stages of A processing clearance and interactions with cellular components
Medchemexpress LLC D-Arabinopyranose | 28697-53-2 | 25 MG
D-Arabinopyranose is a monosaccharide and an analytical standard intended for research and analytical applications. It has been shown to exhibit strong growth inhibition against Caenorhabditis elegans with an IC50 of 7.5 mM.
- Analytical standard for research and analytical applications
- Exhibits strong growth inhibition against Caenorhabditis elegans
- Commonly used in qualitative, quantitative, and methodological research experiments
- Suitable for techniques such as HPLC, GC, and MS
- Reference standard supplied for assay
Medchemexpress LLC (D-Trp6)-LHRH free acid | 129418-54-8 | 99.7% | 1312.43 | 10 MG
(D-Trp6)-LHRH free acid is a luteinizing hormone-releasing hormone (LHRH) agonist. In vitro, (D-Trp6)-LHRH free acid (10 μM; 24 h or 6 days) reduces the proliferation of human epithelial ovarian cancer cell lines EFO-21 and EFO-27.
- Acts as a luteinizing hormone-releasing hormone (LHRH) agonist
- Reduces proliferation of human epithelial ovarian cancer cell lines EFO-21 and EFO-27
- High purity of 99.67%
- White to off-white solid appearance
Medchemexpress LLC PROTAC BET Degrader-10 | 1957234-97-7 | 99.4% | 783.29 | 1 ML
PROTAC BET Degrader-10 (dBET37) is a potent BET protein BRD4 degrader, connected by ligands for Cereblon and BRD4, with a DC50 of 49 nM. This compound utilizes PROTAC technology, containing two different ligands connected by a linker; one for an E3 ubiquitin ligase and the other for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Potent BET protein BRD4 degrader
- Connected by ligands for Cereblon and BRD4
- DC50 of 49 nM
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
- For research use only
- Components include a BRD4(BD1BD2) ligand, a Cereblon ligand, and a linker
- Appearance is a solid
- Color is off-white to light yellow
Medchemexpress LLC 4-Methylumbelliferyl-α-d-mannoside | 28541-83-5 | 99.3% | 338.31 | 5 MG
4-Methylumbelliferyl-α-d-mannoside is a fluorescent substrate for α-D-mannosidase. For research use only.
- Fluorescent substrate for α-D-mannosidase.
- For research use only.
Medchemexpress LLC Integrin alpha 6 bet 5ug
Integrin alpha 6 beta 1 Protein Human (HEK293 Flag-His) is the recombinant human-derived Integrin alpha 6 beta 1 protein expressed by HEK293 with C-His C-Flag labeled tag has molecular weight of 110 130 kDa respectively
Medchemexpress LLC Integrin alpha 5 bet 5ug | 5ug
ITGA5 is a multifunctional receptor that interacts with multiple ligands such as fibronectin fibrinogen PLA2G2A fibrillin-1 (FBN1) IL1B human metapneumovirus and soluble CD40LG ITGA5 recognizes RGD sequences and mediates cell adhesion through different binding sites Integrin alpha 5 beta 1 Protein Human (HEK293 His-Avi) is a recombinant protein dimer complex containing human-derived Integrin alpha 5 beta 1 protein expressed by HEK293 with C-Avi C-His labeled tag Integrin alpha 5 beta 1 Protein Human (HEK293 His-Avi) has molecular weight of 100-140 kDa
Medchemexpress LLC 4-Methylumbelliferyl | 124223-99-0 | MFCD00270047 | 99.0% | 379.36 g/mol | C18H21NO8 | 5MG
4-Methylumbelliferyl 2-acetamido-2-deoxy-α-D-galactopyranoside is a fluorogenic glycoside substrate that liberates fluorescent 4-methylumbelliferone upon α-galactosidase-mediated hydrolysis, enabling sensitive fluorometric measurement of enzyme activity in biochemical and cell-based assays.
- Fluorogenic substrate for α-galactosidase assays.
- Releases 4-methylumbelliferone for sensitive fluorescence detection.
- High purity suitable for quantitative measurements.
- Supplied in small-quantity packaging suitable for assay development.
- Solid form; handle and store according to standard glycoside reagent guidelines.
Cayman Chemical D-GlucuronIc AcId 100g
A metabolite of glucose; a component of proteoglycans; levels are increased in fibroblasts isolated from patients with ISSD or Salla disease
Medchemexpress LLC Integrin alpha 8 bet 100ug
Integrin -8/ -1 coordinates the recruitment of mesenchymal cells during renal organogenesis and recognizes RGD sequences in ligands such as TNC FN1 SPP1 TGFB1 TGFB3 and VTN It plays a role in multiple cellular interactions critical for organogenesis including NPNT as a functional ligand in nephrogenesis Integrin alpha 8 beta 1 Protein Human (HEK293 Flag His) is a recombinant protein dimer complex containing human-derived Integrin alpha 8 beta 1 protein expressed by HEK293 with C-10 His C-Flag labeled tag Integrin alpha 8 beta 1 Protein Human (HEK293 Flag His) has molecular weight of 85-140 kDa
Medchemexpress LLC Integrin alpha V bet 100ug
Integrin V beta 3 proteins specifically the -V (ITGAV) subunit are multifunctional receptors for ligands such as vitronectin and fibronectin and recognize RGD sequences ITGAV ITGB3 binds fractalkine and acts as a coreceptor in CX3CR1-dependent signaling Integrin alpha V beta 3 Protein Human (HEK293 C-His) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 3 protein expressed by HEK293 with C-10 His labeled tag Integrin alpha V beta 3 Protein Human (HEK293 C-His) has molecular weight of 90 31 110-150 kDa respectively
Medchemexpress LLC Integrin alpha V bet 20ug | 20ug
Integrin alpha V beta 6 Protein Human (HEK293 His-Avi) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 6 protein expressed by HEK293 with C-His C-Avi labeled tag Integrin alpha V beta 6 Protein Human (HEK293 His-Avi) has molecular weight of 90-150 kDa
Medchemexpress LLC Bet-bay 002 | 1588521-78-1 | 99.8% | 403.86 g/mol | C22H18ClN5O | 10MM 1ML
BET-BAY 002 is a small-molecule inhibitor of BET family bromodomains used for epigenetic and oncology research. It has demonstrated efficacy in multiple myeloma models and is supplied in solution and solid forms suitable for biochemical and cellular assays.
- Supplied as a 10 mM solution in DMSO (1 mL) and as solid quantities.
- High purity (99.8%).
- Molecular weight 403.86 g/mol and formula C22H18ClN5O.
- Soluble in DMSO for straightforward stock preparation.
- Intended for research use in BET bromodomain inhibition and related assays.